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Ketamine…What’s the deal???
Today, we’re going to be looking at the drug ketamine, answering three key questions
1.How does ketamine work?
2.What are the dangers of using ketamine?
3.What are the potential benefits of using ketamine?
What is ketamine and why am i telling you about it? Well, ketamine is a dissociative anaesthetic. Meaning that it causes a feeling of separation from your environment, and also separation from your body. It can also be used as a recreational drug. At low doses, ketamine can cause a feeling of mind and body separation, seeing trails, a sense of floating and numbness, blurred vision and even hallucinations!
When ketamine is taken in higher doses it can make your legs feel very weak and wobbly
It can make your heart race and you can also fall into a k hole; where you sort of have an out of body experience and you can be floating through space or experiencing all of eternity at a single point in time. But a k hole can also lead to a near death experience where you feel completely powerless and totally confused…Which sounds terrifying!
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That being said, there are no physical withdrawal symptoms for ketamine. So it’s not really an addictive drug, but some people can become reliant on it with a sort of psychological dependence and you do start to become more tolerant of ketamine. Meaning you need a higher dose each time to get that same dissociative effect and as you take more ketamine, you increase your risk of overdose. An overdose on pure ketamine is pretty rare. You would need to consume a lot!
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So how does ketamine actually work? Ketamine is an antagonist of ndma receptors which are found in nerve cells
And ndma receptors allow the nerve cells to transmit signals. So by antagonising these receptors, ketamine reduces the amount of signalling throughout the body thereby reducing pain levels, reducing muscle control and reducing brain signalling in general. And the effects of ketamine last for around an hour or so, depending on how much you take
Ketamine is a horse tranquilizer! If you were to, say, accidentally ingest some ketamine
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Here are the kind of dangers that you might want to look out for injury! When you’re on ketamine, you can’t feel pain
And you’re probably being really clumsy, so you could potentially injure yourself really badly, without even realising
Vulnerability! As you lose control of your muscles and your mind loses its hold on reality. You put yourself in a really vulnerable position to be hurt or taken advantage of by others. So be really mindful of that!
Looking long-term, if you use ketamine often side effects can include: stomach pain, kidney problems and bladder damage. This is because ketamine is toxic. It really damages our organs as it passes through the body
And it’s excreted through the urine, so it sits in the bladder for quite a while. Causing ulceration, inflammation and scarring
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Research is currently being conducted to determine whether ketamine can be used for treatment resistant depression. That is, depression that is unaffected by 2 or more different antidepressants ketamine administered by doctors to patients has been shown to have a rapid antidepressant effect that can last for several days. And researchers believe that this is because the ketamine is promoting a complex signalling cascade. Which is resulting in more synapses and increased neuronal connectivity particularly in the prefrontal cortex of the brain. However, there are no long-term studies looking at the safety and efficacy of ketamine as an antidepressant